I have been seeing this ALOT lately, Had to restore 3 machines just today.
Mach3 runs perfect.  Client shuts down and goes home.  The next day they open mach3 and get the (See attached image).  Its asking for the motion controller, custom screenset not loading and all the settings in the XML are zero.  Have been seeing this for months on windows 10 and windows 11 computers.
I have been trying to research this, at first I though it had to do with windows updates as some of my clients I just cannot convince them to take the box off of the internet.   Not so sure now.

Any ideas?
Thanks
Rob