It's possible. Plenty of graphics cards let you run double monitors. I'm running a Dell laptop with a dock and two DVI connected monitors for 3 screens total. It's a sweet ride to efficiency when running Solidworks and five other things at once. Best of all you can use a triple width background for the final touch of awesomeness.
Mouse coordination is easy. Identify and place monitors using Windows' resolution setup and the desktop extends from one to the other. You can put monitors side by side, or stack them. Use two identical ones if you can.