Finishing one run then packing up for the night and then the next day putting a new piece in and expecting to just match up and run another time but my coordinate haves to be re zeroed for the new piece. The new piece is exactly in the same spot and the router head was not moved. 

Persistent DRO's in general config

currently it is selected

Depending on the accuracy needed this may not be the best practice as shutting down and starting the computer and Mach may move the motors slightly. If that is not an issue then great
 Have you got persistant offsets checked? Have you got copy G54 from G59.253 unchecked?
Can you attach your xml and I will have a look and see if I can find a problem.
Hood

here are the settings, the motors don't move the amount that it is off.

z's dro though remains unouched, while x and y can be anywhere from an inch to 10 inches off.