It would all depend on where you stand and routers tend to be the users that have the most problems as the position you stand at is often different from the natural X and Y.
The Home position can be any place you like but the machine coords zero should be as on the screen, lower left corner., in other words tool furthest negative on both X and Y. The reason I say the Home can be anywhere is because you may wish to home to a different location than machine coords zero and Mach allows you to do that by entering a Home Offset value. As an example it is better on a knee mill to home the Y axis fully positive as that means the table is nearest the operator. So what would be done is a Home Offset value equal to the axis travel is entered into the Homing page and when the machine is Homed the Y would have that value as Machine Coordinates rather than the normal Zero.
All of the last will unlikely apply to you as you have a router. Then again it may as like a knee mill it may be better for you to home a certain way to make material loading easier.
Hood