I do the exact same thing you want to do with my router.
In Mach3, try using a Home offset of 48 in Config > Homing/Limits, which will make X zero at the far left when homing. You may need to play with the number a little to get it where you want it.
Then, in V-Carve Pro, change X home position in Material Setup to 48 instead of 0. Or maybe 47.5, or a little bit less than the Home Offset you used in the above step.