This question has probably been asked, but is there a setting that will save/remember values in the DRO's on a power loss, reboot or program shutdown?

Mach3 saves settings on shutdown so there is nothing to save settings on a power loss . A UPS will help IF mach3 AND the machine run off the UPS. You must of course stop and shut down Mach3 as soon as possible.

There is a General config setting to save DROs on shutdown as well as fixture settings.

(;-) TP

Is that the persistent DRO's checkbox?