When I use the Mach 2/3 post processor in Aspire and then load the G-Code into Mach 3 it switches the x and the y axis in the tool path screen. Is there a way to change this. I am using the front left corner of the CNC machine as the home position.

That's an unusual problem...

Does your machine have the X axis Left to Right and the Y axis Front to Back ?
In Aspire, check that you are setting the work datum point as the front left corner.

Tweakie.

In Aspire the work datum point is the front left. Also, in Mach3 the number values all show them going up as you move the spindle in either of the three axis away from the front left corner. But when you run some gcode it shows the x and the y axis switched so it looks like the work piece is inverted and then rotated 90 degrees.

you are not giving enough information.  We do not know if you zeroed all the X Y Z and A work coordinates.
We do not know that your machine is configured to jog the correct directions.