Finally was about to finish my plasma cabinet, went to boot up Mach4 and suddenly I'm getting this error. Retried many times an even the ESS will lose connection so I run the SCU to detect it again. Everything was doing well then this. Was running fine earlier today so not sure what suddenly cause this problem?

Found the profiles machine.ini instruction but no luck.

I was able to get into Mach now by reinstalling it but Mach still says it doesn't see the ESS but the SCU does.

Did you power cycle the ESS, if you had a bad shutdown it can cause issues and power cycling should fix it